Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array

Sophie C Payne; Peregrine B Osborne; Alex Thompson; Calvin D Eiber; Janet R Keast; James B Fallon

Journal article

Selective recording of physiologically evoked neural activity in a mixed autonomic nerve using a minimally invasive array

Sophie C Payne, Peregrine B Osborne, Alex Thompson, Calvin D Eiber, Janet R Keast, James B Fallon

APL Bioengineering | AIP Publishing LLC | Published : 2023

DOI: 10.1063/5.0164951

Abstract

Real-time closed-loop control of neuromodulation devices requires long-term monitoring of neural activity in the peripheral nervous system. Although many signal extraction methods exist, few are both clinically viable and designed for extracting small signals from fragile peripheral visceral nerves. Here, we report that our minimally invasive recording and analysis technology extracts low to negative signal to noise ratio (SNR) neural activity from a visceral nerve with a high degree of specificity for fiber type and class. Complex activity was recorded from the rat pelvic nerve that was physiologically evoked during controlled bladder filling and voiding, in an extensively characterized in ..

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University of Melbourne Researchers

Sophie Payne Author

Peregrine Osborne Author

Alexander Thompson Author

Janet Keast Author

Related Projects (1)

Understanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.

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Grants

Awarded by Research reported in this publication was supported by the National Institutes of Health, Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, Award No. OT2OD023872. The content is solely the responsibility of the

Funding Acknowledgements

We would like to acknowledge Ms. Amy Morley, Ms. Philippa Kammerer, and Mr. Jerico Matarazzo for laboratory assistance, Mr. Ross Thomas and Mr. Peter Phan for the manufacture of the array design, and Mr. Thomas Tonroe and Ms. Erin Smyth for technical support.r Research reported in this publication was supported by the National Institutes of Health, Office of the Director, Stimulating Peripheral Activity to Relieve Conditions (SPARC) Program, Award No. OT2OD023872. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The Bionics Institute also acknowledges the support they receive from the Victorian Government through its Operational Infrastructural Support Program.